Anomia plays off the fact that our minds are positively brimming with all sorts of random information: things to eat, pop songs, websites, etc... Sure, under normal circumstances, it's easy to give an example of a frozen food or a dog breed, but you'll find that your brain works a little differently under pressure!
To play, draw and reveal a card from the center pile. Does the symbol on your card match one on another player's card? If so, you must quickly face-off with the other player by giving an example of the person, place, or thing on his card before he can do the same for yours. If you blurt out a correct answer first, you win his card and the drawing continues.
Sounds simple, right? Wrong! Wild cards allow unlike symbols to match, increasing the number of things to which you must pay attention. Cascading face-offs can occur when you hand over a lost card, thereby revealing a new top card on your play pile.