The board consists of a 7x7 array of plastic squares, each of which has an arc cutting two diagonally opposite corners.
The rest of the equipment is a deck of 52 cards showing various closed amoeba-like curves that can be made with the arcs - players get 3 of these to start and are trying to create the curves shown on their cards.
On a turn a player gets to rotate any piece except the one last rotated, and if a needed shape is made, the player gets the points shown on the card, a new card, and another turn. The first player to reach 50 points wins.
Amoeba has been published as 'Tantalus' in the Ravensburger Casino Series.