The Bureau for Paranormal Research and Defense (the B.P.R.D. or BPRD) is a fictional organization in the comic book work of Mike Mignola, charged with protecting America and the world from the occult, paranormal and supernatural. It maintains the services of several supernatural persons, including Hellboy. The B.P.R.D. originally appeared in the Hellboy comics but has also been featured in many stories under the B.P.R.D. title.
The BPRD is a well known and respected organization that has excellent relations with most international governments and United States government agencies, with the exceptions of China and the CIA. The Bureau was the United States' only defense against an onslaught of frog creatures (originally featured in Seed of Destruction). Though the 'frogs' began operating on the East Coast, they spread west on both sides of the US-Canadian border. To cut costs, the Bureau moved from its traditional headquarters in Connecticut to an abandoned research facility in Colorado. This facility was last used to house Nazi scientists who defected to America after World War II. As such, the facility contains vast quantities of secret files that the BPRD has yet to explore.
The frog monster invasion reached its peak during the events of The Black Flame during which a Neo-Nazi madman adopted the persona of the World War II era supervillain the Black Flame and insinuated himself as the leader of the frogs. Together they raised the gigantic Katha-Hem (one of the Ogdru Hem, the 369 spawn of the Ogdru Jahad) which ran rampant across the American heartland until Liz Sherman used an ancient artifact to amplify her pyrokinetic powers a thousandfold. After Katha-Hem was destroyed, the frog monsters dragged the Black Flame into a vast pit and the invasion appeared to come to an end.
His destructive programming is taking effect. He will be irresistibly drawn to large cities, where he will back up sewers, reverse street signs, and steal everyone's left shoe.
626 was designed to be a monster, but now he has nothing to destroy. You see, I never gave him a greater purpose. What must it be like to have nothing, not even memories to look back on in the middle of the night?