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I was saying boo-urns
One of the game ending conditions is if you can't fill the lineup back to 5 cards.
If I had a card that destroys a lineup card and replace it with another card from the main deck... What happens to game if no main deck and there are less than 5 lineup cards?
Destroy the card, no replacement, turn continues
Game ends immediately
NA NA NA NA . . .
The game would end immediately. The requirement for game end is specifically when you cannot fill a spot in the line-up. If a card asks to refill (or add more cards past the 5) to the lineup and there are no cards in the main deck, the game is over.
The same for when you buy the last Super-Villain from the stack. The game ends immediately so you can't do effect combo's to somehow play your newly acquired S-V.