Each two-player game in the Army vs. Aliens series is playable on its own, but any faction in one game can be played against any faction in another. In addition, multiple sets in the series can be combined for team games or "last man standing" challenge matches.
To play any game in the series, each player takes one of the factions and rolls all nine dice. Taking turns, players then either attack the opponent or use a special power. Dice that are used are placed into the dice cup. If a player cannot attack or use a power, he instead "rallies", rolling the dice cup and simultaneously rerolling all of his dice still in play.
The two forces in each game have different special powers, and players want to use these powers (via their die rolls) to move dice into their scoring zone. If five rounds pass without either player scoring, then the game ends and the player who has the most dice in his scoring zone wins.