The game plays much like standard UNO, with the addition of 4 special "Beam Up WILD" cards that can negate the effects of any DRAW 2 or DRAW 4 WILD cards played against a player. That player can then call a new color, and play resumes as if they had played a regular WILD. (It can also be used as a regular WILD if desired.)
EXAMPLE: Player 1 plays a DRAW 4 WILD card and calls a new color. Instead of having to draw 4 additional cards, Player 2 plays a "Beam Up" card and doesn't have to draw ANY additional cards. Player 2 then calls a color, and play continues as normal, with the next player trying to play a card in the color called by Player 2.
NOTE: Unlike the 4 different types of "special WILDs" in the Mattel set, this is the only non-standard type of WILD card in this set. It does, however, mirror the effects of the "Beam Me Up, Scotty" card in the Mattel set.