From the LooneyLabs.com website:
Fluxx is going into Target nationwide!
Now available exclusively at Target stores, this new version of Fluxx has been designed specifically for the mass market.
Packaged in a tuck box (not our standard 2 part box) and simplified to contain only the four basic card types (Keeper, Goal, New Rule, and Action), 73% of the cards are fundamentally unchanged from the current Fluxx 4.0 game sold in game stores.
The more complex cards in 4.0 have been removed, and 11 cards that have been seen before in other versions or as promo cards have been included. There are 16 all new cards, most of them Goals that combine long time Keepers in fun new ways.
The Keeper artwork has been updated with new illustrations by Michael Hays.