Werewolf: The Apocalypse is a game about the Garou, werewolves who believe they were placed in the world by Gaia to protect the weaker species and fight against The Wyrm.
Most of the werewolves live in the wilderness, avoiding the cities, and fighting against the encroaching civilisation (while at the same time wondering if they should still protect the humans as well). But there are more struggles. Vampires and The Wyrm are ever-present and need to be dealt with. At the same time, younger werewolves may find themselves struggling with their identity and the rigid traditions and hierarchy of Garou society.