There are two general principles I use in playing heroes: hero selection and time management.
The first thing is picking your heroes and giving yourself the opportunities for potions and hearts. Look to your Attack or Dex profiles for this. You'll want a blend of blues and reds for your team. Use loot & relics improve your heart/portion production.
The next guidelines underpin any hero combination I use.
Time management (adventure tracker) & movement.
Because spawn point give Bosses an extra activation, you'll want to destroy all ASAP.
I play with a general principle: aim to kak 2 spawn points by 16bit. It usually means by the Adventure Tracker hits SUPER! I am on my way to killing the third.
From there I see chance and matchup opportunities that drive the gameplay, but I look at that as advanced gameplay.