San Francisco Bay Area
(Non-Promo Federation) Spock is banned from our 2-player games by mutual agreement.
We haven't gone quite this far, but NPF Spock and Abraham Lincoln are both very fast victims of the 'defensive search'.
A combo that hit me hard recently: NPF Kirk and Gary Seven. My opponent had a bundle of tribbles in his discard pile, and solved one of the 'trash up 2 cards in your discard pile' missions, so I got 6 new tribbles. Ouch.