Yes, it is. Cape of Escape would do it. So would the Giant Badger (though that isn't around for Iesha Foxglove). Though I'd personally say that would only be possible if you closed the location by virtue of defeating a henchman. If you got to attempt to close it because it had no cards, then you've already moved past the "explore" part of the turn and can't explore anymore.
For Iesha, if you've encountered the Skinsaw Man once and he has fled to another location, then it is possible for him to be in the same location as the Haunt which triggered your encounter with Iesha. Which means that it is also possible to find him in the location you are at when you encounter Iehsa.
For Underneath Sandpoint, being force to "reset your hand and end your turn" means that you can not play cards or use powers when applying end of the turn effects.
Rulebook v3 p9 wrote:
Reset Your Hand: First, apply any effects that happen at the end of the turn; if a power allows or directs you to not reset your hand, you must still apply any effects that happen at the end of the turn. You may play cards and use powers unless a power directed you to reset your hand and end your turn. After resolving these effects, you may no longer play cards or use powers for the rest of the turn.
That means that Seoni can't use her "auto-succeed" power to recharge any spells she has displayed (like Toxic Cloud). And Lini can't reveal an animal ally for an extra d4 when she attempts to recharge a spell like Toxic Cloud. You also can't play a movement spell like Haste. And Lem couldn't use his swap ability at the end of the turn.
So there are other penalties that go with that.