"that's a smith and wesson, and you've had your six"
As one of the few people who will respond that has actually spent some time in Karachi. I will say while working with the Karachi Navy, I did have a chance to play quite a few boardgames with several members. Of course this was in 1989, but they did seem to enjoy it.
Karachi is a very very poor city, I am guessing you are going to have a hard time finding locals to game with. But if you are going in a capacity with other foreigners, you might have luck getting something together.
I couldn't imagine why you would be going there in this climate. But good luck!(And take your malaria treatment)