I've read the rules and it seems well adapted for 2 players. There are neutral submarines blocking empty spaces, a smaller amount of resources, and a smaller loading area. I'm pretty confident it plays well with two.
Tolerance for ambiguity is the first step in maturity.
Two is ideal for learning the game and trying out new strategies, I think the decisions are much more painful once you hit 3 players. There's a real sense of racing around and competition with 3 that I appreciate. And I must say that I equate a little bit of decision pain as a good thing when I sit down to play a Feld. But two works very well for Aquasphere.
On the Kickstarter, we did a 2-player walk through. Rahdo's video play through from today is better because he shares more of his thoughts: