Stand By, Ready
i dont think the orb has any hand icons, so its always considered in effect.
The Orb had a hand Icon (last time I checked it, so it could have mutated in the last couple of days) and so its text is only in effect when held.
Arguably penalties might still apply since the rule is benefits of card text only applies when equipped but that would need one to be sure corruption hits weren't beneficial. And with the orb that isn't automatically true.