Might be playing this wrong/ The wife and I are playing. I use Pegasus to select a card out of her hand--I select Pandora - Do I lose all my cards or she does?
She does. See the second bullet under Pandora on page 6 of the rules.
1 more now I think about it. First row- a card is face up can I play a face down card in fornt of it if I have room in my column?
Yes, you can do this.