Mode: Advanced Solo+Final Blow Mastermind: Wasteland Hulk Scheme: Smash two dimensions together Villains: Wasteland, Streets of New York, Savage Land Mutates Heroes: Old Man Logan, Wolverine (X-Men), Hawkeye
None of these heroes have any recruit cards, so you'll be relying mainly on attack for the bribe-able villains, making them extra tough.
Good KOing potential with Old Man Logan, with potential to draw your whole deck if you can thin it out, but again be careful not to KO all your recruit cards before your deck can generate enough attack for that final blow- you'll need 19!
You may even need to recruit some SHIELD officers!
I've tried it once so far, and thought I was doing Ok until I realised that was just because all the scheme twists were clustered together a little further down in the deck. Never saw a 'lone survivor' card to get the KOing going, and then I got 4 twists in a single turn. Two turns later I got the next four and that was game over.