I actually think drink routes are quite important. I recently won a game taking errand boy first as there was only 1 yellow drink sign on map
Ditto! (New business developer + Luxury Manager is also great in this situation, especially at 2-3p, as there will be so much demand that even if other players pick up a lot of sales, you will still have plenty left with gardens+LM to stay well ahead)
As for other considerations:
-Overpasses -- sometimes on split boards, you can place entrance to open on both tunnel and its overpass, giving you access to all areas
-Types of advertising -- is the board setup well for mailboxes with a large swath of whitespace/houses? Are there tight clusters good for airplanes?
-and of course, reacting to others if last to ensure no one has a clearly superior position