"Music That Glows In The Dark"
The symbols for black and blue materials are different. I have assumed that those types of materials not not interchangable. If you ignore this, and assume that black is black and blue is blue, then there's no reason why you couldn't combine the sets.
If you assume as I have that different symbols keep things separate, then the only parts from Antiquity that are still usable for Middle Ages are the loans and education cards (neither of which were common in the Middle Ages anyway).
I have not tried to mix the sets together, not have I wanted to.
If you had to pick one over the other which would it be?