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I've only played one game and we had two "dex" challenges that came up. Stacking dice and pulling a paper.
I know some people that have cerebral palsy, mild, but hand control is an issue.
So do they just take the failure for not being able to do these tasks?
Just make them roll against their agility score (or whatever seems most suitable given the challenge). Having fun is the aim, and an auto-fail isn't great.