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"Life before death, strength before weakness, journey before destination." - The First Ideal of the Lightweavers (The Stormlight Archive)
I noticed this today when checking all my outstanding CMON pledges on the pledge manager.
Naturally, this doesn't necessarily mean that shipping has really commenced, but it does mean that you can't update an address in the pledge manager directly now.
If I had to guess, it probably means that packing the games into the containers for the ships has commenced. They pre-package/address all pledges at the factory before even loading on ships; this is why you can't update your address anymore.