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I actually like the space theme better, but it occurred to me that you could probably site it in WWII with a convoy raider like the Graf Spee fighting off the British or with a British cruiser in WWI raiding the Germans.
The shields would be armor. You might have to do the game in bursts of 4-6 threat cards after which you gave the ship some chance to restore the armor while letting them do repairs anytime? Not sure. No nebulas or asteroids but there would be terrestrial equivalents and so on. Orouboros would be some enemy Battlecruiser.
Nothing serious, just idle thoughts.
I tackled this as a thought experiment and posted my ideas under the "deep sea d6" thread - a near future submarine combat setting, the engine could easily be adapted for other settings!