For a game that is more focused on dungeon delving, try removing the following cards from the game:
If you are using the 'Sunken Treasures' expansion also remove:
When using this variant in a two and three player game do not remove any artifacts during initial setup.
I strongly suspect these changes have the effect of making most Skill-granting cards less useful. One of the big rewards of having lots of Skill generation in your deck is being able to grab a ton of Secret Tomes on the dash out.