In all the pictures and videos that I've seen, it looks like this game takes quite a bit of real estate to set up. Will this fit on a 4-foot square table, at least for a 2-player game?
Do you mean just the base game, or with the co-op scenario boards from the expansions? Just going off of memory a 4' square table should be enough for two players sitting on adjacent sides, for the base game and at least some of the expansions. You might still want a side table or TV tray for the market goods and un-built buildings.