I just purchased this and am eagerly awaiting. With a game thats probably gonna be impossibly to find in a year or two, I want to sleeve the game fully.
What are the card counts and sleeve sizes?
I also got the Outer planets expansion
https://boardgamegeek.com/geeklist/164572/item/4091721#item4... has all the info you need. In short: sleeve the mini-american cards (outcomes and components), missions, and spaceship/technology cards. You can sleeve the locations, but it's going to be an adventure and probably not end too well. Probably not worth it.
Also, the individual card sizes are very inconsistent between printings, so your copy may have different location card sizes.