As a supplement to question 1:
If a card has been depleted, other abilities on this card are inactive.
Official FAQ wrote:
When a card is depleted, abilities on that card no longer have any
effect. For example, if MHD-19 uses the “deplete” ability on his
Reward card, “Systems Upgrade,” that card no longer provides the
“+2 Health” ability, and MHD-19’s Health value is immediately
reduced by 2