Hi Matthew Thanks Andrew. Good work on the game
I'm the creator of Anomia. You can definitely play a two-player version.
Basically, you need to understand how the regular game works for three or more players. Then, in the two-player variant, each player defends two Play Piles, instead of one.
Draw cards, one at a time, and if there is a symbol match or Wild Card match, then you face off just like the regular game.
Note: If you draw a card that matches a symbol on your own side, then both players attempt to give an example of the just-drawn card.
Essentially, you are replicating a 4-player game for two people.
Hope that helps!