Can he target enemies standing one zone away?
Yes, as per his Special Skill - Huge:
Lil' Ned wrote:
Melee Actions have Range 0-1
Do his melee attacks always get an automatic hit?
No, this was likely changed from the kickstarter campaign to the actual printed version. It could have possibly been referring to either Lil' Ned or the Bonecrusher class, but neither have an "automatic hit" that applies always.
It could be referring to the Bonecrusher free class skill "First Blood":
When the Hero enters an Enemy's Zone or an Enemy enters the Hero's Zone, inflict 1 Wound to the Enemy.