The CoH Solo expansion is a rather elaborate system. I am not really sure if this will match well to a fast playing game like Agents of Mayhem.
As a side note:
With two players (1 vs. 1) the player on Mayhem side will play 3 agents. But Legion side has some more options (as far as I understand, a whole group of 3 troopers counts as one unit). So it's some kind of asymmetric warfare).
However, with the Kickstarter stretch goals allready unlocked you can play with up to 8 player (4 vs. 4).
Even more, if you choose the AI add-on (based on the Academy Games CoH Solo Expansion) you can use the AI for every player you like. So you can play 1 vs. AI (solo play), 2 vs. AI (CoOp) or 1+AI vs. 1+AI if you like - and much more. If you realy want, you clould make a game just using the AI and no real player.