I am called Huginn..., or is it Muninn..., I forget...
I haven't had a chance to actually play it yet, but after reading the rules I can't see any reason why it wouldn't work solo.
The only hidden information is the (2-5) player hands and they're only 2 cards. You could "play" one hand and turn the others up blind, or if you really like chaos and random-ness (like me) you could play all the hands that way.
Or just actively play them all. It still seems like it would work.