OMG! Overtext! How long have I been sleeping?! OVERTEXT! Also, I'm a DESIGNER now?! Sweet! OVERTEXXXXXXT!
HO HO HO! Give me some money!
Yes, it can.
When the last Letter Card is drawn, the game immediately ends (unless a card is played to prevent this, like the 'Flop Boat' for example).
As taken from the designer's thread on tie-breaking: http://www.boardgamegeek.com/thread/215745