I've mainly played this with four, but played for the first time with two last weekend. There was definitely more direct conflict with two, playing Aquilonia and Turan as recommended, but otherwise the game scales down well from the four player version. It offers the same basic game experience. If you wanted, you could mod it to play two factions each, using the existing bid system to vie for control of Hyperborea and Stygia between each Age Change. That could be interesting. But anyway, the point is out if the box two player plays well.