What's the best NUMBER of investigators and who are the best INVESTIGATORS to use in this game, because I've never won and played it quite some times. It's getting so frustrating that I'm losing interest in it!
I'm also a new player that plays with AH and a few Lurker's components.
Do not add expansions that are for experienced players that like to play many investigators.
You'll probably get the best results with 4 investigators.
Get Mandy and Joe Diamond.
Then add any two of these, depending on your strategy: Harvey (with a good weapon can face tough monsters); Lee (Stamina recovery); Darrel (good all round); McGlen (firepower); or Jenny (cash).
This should provide you with a win rate well over 50%.
If you draw the Terrible Experiment just gang on with all you can to eliminate that card.
If you want a fairly sure win: get Nyarlathothep, Ithaqua or Yig and amass weapons and clues to defeat them in the final battle.
Yig only: save some trophy's to get blessed by the endgame.
Ithaqua: a litle more sophisticated, but get Allies at Ma's that give Fight bonuses as soon as you can. Do not waist precious clues closing gates, instead close them and trade for more clues and Allies.
In all the above cases:
Close gates and do not seal them unless you feel you have a load.
If you do seal, seal only Unvisited Isle, Witch House, Woods, Black Cave and Independence Square.