By all means. This is why I mainly left the fluff in the scenarios, not as much in the rules. This is also why the dice pool system is a bit abstract, so the players can use whatever setting they want.
The sceanrios I produce will continue to take place in the Outrider universe.
All down to the choice of vehicles, really. No modifications to rules or play or anything but the fluff.
The setting is a slightly different, better armed version of the depression and prohibition era in America. Bonnie and Clyde, Dillinger and the rest give the basis. The origional moonshiners and shinerunners have given way to better armed and hotter engined gangs. Gangs fight each other for turf, and the Feds and Rangers try to keep the peace through advanced firepower.