Its just theoretical question.But the first time one of my mate's played it he scored 46.He's the type of player who that's always gets a much better score on the second or third play.After he can see combos to put off.
There are a fixed maximum number of points available, so I think it's unlikely without someone intentionally helping. If you scored 5 points in each district in each scoring round (theoretically possible with enough resource guilds) and a player choosing not to build or acquire people, you could score 25 district points, plus 9 for personnel for a grand total of 102. As a practical matter, only in a 2 player would you get more than 2, and with ties bumping you down in scoring, the maximum drops very rapidly from that figure given even a small amount of resistance from a single opponent. In addition, it's unlikely all potential scores will happen in the first scoring.
I'm finding it hard to imagine 50+ without a resource rich game and a poor opponent.