The most similar game I've probably played is Munchkin, and I have to admit, I quite enjoyed it. It wasn't as brainless as I thought as there was definitely some strategy in keeping certain cards in hand, helping the right people, and denying help/treasure to other people.
Epic Spell Wars looks like a very interesting game in the same mold. But there seems to be little reason to not play cards in hand, or save cards for later use. There also seems to be few/no "defensive" cards in the game so you really have no choice but to take whatever is thrown at you. The only strategy seems to be whether to play 3 or less cards. That doesn't seem much and seems to be even more simple than Munchkin.
I haven't seen all the cards yet so I could be wrong. And perhaps Munchkin will turn out to be as brainless as I thought. So take the above with a grain of salt.