Will M. Baker
So the familiar will never be in your hand in either the dungeon or the village...
One nuance to this:
TS7 p.12 wrote:
Your hand consists of all cards you have drawn this turn and have present. Familiars are considered part of your hand.
So even when the Familiar is set aside for later use, it is still considered part of my hand. From this we could conclude (but not sure if this is right):
1) When discarding/destroying a card in my hand, my Familiar is a legal target. (E.g. Thunder Wrath could destroy my Familiar.)
2) Any card that referenced my hand size (e.g. Verdan) would include the Familiar.