I play with 3 players and LOVE Little Duckling. However I HATE having to mess about with handicaps. So I tried S2-7 Mission 7 from the original Sitting Duck; a full 12 turn 3 Phase mission. We scored +26 points killing all 28 points of threats with one damage and one knocked out battlebot.
We used a 'tougher' Little Duckling as follows:
Begin game with full shields and reactors and 12 damage tiles All 3 Computer blocks work as in Sitting Duck. Crew start where they like. 6 cards for each phase for each crew member plus one random heroic card per crew member. That was all. White references went to Red.