I've played Pandemic a few times now, and won multiple times, with my friends. But we have never beaten the game in the four-player variant.
Do you make slight variations to the game? The only way we've gotten close to winning in the four-player variant is to say that if you simply treat a disease to its eradication, without actually finding the cure, that that counts as eradication.
??? I guess we're cheating...
4 players is more difficult and you don't say how many epidemics you're using, but just a question. You did know that you don't need to eradicate a disease to win, only cure them all?