Baron Blade's setup card says that if 15 or more cards make it to villain's trash, the Impulsion Beam gets activated - game over.
Does the Impulsion Beam card have to be in play for this effect to happen? I can see pros and cons to either approach.
There isn't an Impulsion Beam card, from memory. If you mean does he have to be on his starting side, then yes, he loses his special victory condition once you've destroyed him the first time (smashed up his Impulsion Beam Generator Laboratory, or suchlike).
If that's not what you meant, I don't know what you mean.